The Therapeutic Journey of Quinazoline as Anti-cancer Targeting Kinase Inhibitors

Abstract

Cancer is a group of different diseases that can affect various parts of the body through abnormal cell growth. Many existing chemotherapy agents are highly toxic and lack selectivity. This often results in treatment resistance. Therefore, there is a great need for targeted chemotherapeutic agents with minimal side effects and high selectivity for cancer treatment. Quinazoline is a crucial structural scaffold known to be associated with various biological activities, including amazing anti-cancer effects. Several recognized anticancer quinazolines act by various molecular targets and mechanisms. This review aims to explain various aspects of medicinal chemistry, such as drug design, the relationship between structure and activity, and the mode of action of quinazoline derivatives specifically targeted against cancer. In addition to focusing on the key preparation strategies of different quinazoline derivatives. It provides a comprehensive overview of the chemotherapeutic effects of quinazolines as well as synthesis in terms of drug discovery and development.