Revistes Catalanes amb Accés Obert (RACO)

Alzheimer’s disease early detection from sparse data using brain importance maps

Andreas Kodewitz, Sylvie Lelandais, Christophe Montagne, Vincent Vigneron,


Statistical methods are increasingly used in the analysis of FDG-PET images for the early diagnosis of Alzheimer’s disease. We will present a method to extract information about the location of metabolic changes induced by Alzheimer’s disease based on a machine learning approach that directly links features and brain areas to search for regions of interest (ROIs). This approach has the advantage over voxel-wise statistics to also consider the interactions between the features/voxels. We produce “maps” to visualize the most informative regions of the brain and compare the maps created by our approach with voxel-wise statistics. In classification experiments, using the extracted map, we achieved classification rates of up to 95. 5%.

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